Information for Special Populations and the COVID-19 vaccine

Guidance rapidly changes as we continue to learn more about COVID-19. We encourage you to review the Centers for Disease Control and Prevention’s (CDC) website for the most updated recommendations.

COVID-19 can cause severe medical complications and lead to death in some people and vaccination can help protect you and others around you from COVID-19.  In certain circumstances, people may be advised by their doctor to receive a specific type of COVID-19 vaccine or to delay vaccination due to immunosuppressing medical treatment or surgery to a future date when immunization is more likely to have an effective immune response. Pregnant and lactating people are recommended to be vaccinated against COVID-19.

Can people with allergies get the COVID-19 vaccine? Yes, in most cases with 2 exceptions:

  1. People with a severe allergic reaction (anaphylaxis) to any component of either an mRNA vaccine or the Johnson & Johnson COVID-19 vaccine should NOT receive that vaccine. Many people will be safely able to receive an alternate vaccine. An allergic reaction is considered severe when it is classified by a healthcare provider as an anaphylactic reaction or a person needs to be treated with epinephrine or EpiPen© or if the person must go to the hospital.

If You Are Allergic to Polyethylene Glycol (PEG) or Polysorbate

  • PEG and polysorbate are closely related to each other. PEG is an ingredient in the mRNA vaccines (Pfizer and Moderna), and polysorbate is an ingredient in the Johnson & Johnson (J&J)/Janssen vaccine. If you are allergic to PEG, you should not get an mRNA COVID-19 vaccine. Ask your doctor if you can get the J&J/Janssen vaccine.
  • If you are allergic to polysorbate, you should not get the J&J/Janssen COVID-19 vaccine. Ask your doctor if you can get an mRNA COVID-19 vaccine.

2.  People with a severe allergic reaction (anaphylaxis) to any vaccine or injectable (intramuscular or intravenous) medication should consult with their health provider to assess risk prior to receiving the COVID-19 vaccine.

More information about allergies and the COVID-19 vaccines can be found on the CDC website. The medical exemption request forms must be accessed on the Yale Vaccine Portal, then uploaded once completed prior to being submitted to the university’s COVID-19 Vaccine Medical Exemption Review Committee. Learn more about the exemption request process here. 

Everyone else with severe allergic reactions to foods, oral medications, latex, pets, insects, and environmental triggers can  get vaccinated against COVID-19.

People with severe allergies require a 30-minute observation period after vaccination, while all others must be observed for 15 minutes. Vaccine clinics have safety protocols in place to respond to any adverse reactions.

If I am pregnant or breastfeeding? 

COVID-19 vaccination is recommended for pregnant people and people who are breastfeeding. Pregnant and recently pregnant people are more likely to get severely ill with COVID-19 compared with non-pregnant people. The CDC and the American College of Obstetricians and Gynecologists recommend COVID-19 vaccination for people who are pregnant, recently pregnant, planning pregnancy and those who are breastfeeding. Accumulating data provide scientific evidence of both the safety and effectiveness of COVID-19 vaccination in pregnancy. CDC strongly recommends COVID-19 vaccination either before or during pregnancy because the benefits of vaccination for both pregnant persons and their fetus/infant outweigh known or potential risks. COVID-19 vaccine is recommended for people who are breastfeeding. CDC and reports have shown that breastfeeding people who have received mRNA COVID-19 vaccines have antibodies in their breastmilk, which could help protect their babies. Getting a COVID-19 vaccine can prevent severe illness, death, and pregnancy complications related to COVID-19.

The CDC is continuing to collect data on vaccinated pregnant people through the v-safe COVID-19 Pregnancy Registry. If you are pregnant or breastfeeding you may wish to discuss the benefits and risks of the vaccine balanced with the risks of COVID-19 infection with your healthcare provider. While a conversation with your healthcare provider may be helpful, it is not required prior to vaccination.

Should people with autoimmune diseases receive COVID-19 vaccine?

The CDC provides updated guidance on COVID-19 vaccines who are moderately or severely immunocompromised. People with autoimmune conditions are at higher risk for severe illness from COVID-19 infection and vaccination is recommended in most cases.  If you have an autoimmune disease, consult with your healthcare provider to discuss the risks and benefits of vaccination. If you and your health care provider feel that it is appropriate to pursue a request for medical exemption, you must access and submit the form on the Learn more about the exemption request process” webpage. Medical exemptions may be granted on a temporary basis and are subject to reassessment.

Should I get the COVID-19 vaccine even if I’ve already had COVID-19?

The CDC provides guidance about getting your COVID-19 vaccine after having COVID-19

  • Those with a booster requirement who wish to delay their booster may request a temporary medical exemption for up to 90 days with evidence of a positive test.
  • Individuals may wish to discuss optimal timing with their primary care clinician based on their individual risk profile.

Updated September 16, 2022